Portrait of Dr Graham Williams Dr Graham Williams

View research degree topics that Dr Graham Williams might supervise

g.a.williams@hud.ac.uk | 01484 47



Biography

Graham Williams graduated from the University of Leeds in 1998 with a BSc (Hons) in Physiology. He then went on to do an MSc in Neurosciences at the Institute of Psychiatry, King’s College London. His research thesis was titled 'The signal transduction pathways of the abnormal prion protein'. He has a PhD from the University of Huddersfield with the thesis title of ‘Identification and Resolution of Capability Gaps in Forensic Science’, which is centred around forensic genetics.

From 1999 to 2002, Graham worked in the Neurosciences Group of the Weatherall Institute of Molecular Medicine at the University of Oxford researching the auto-immune aspects of epilepsy - investigating possible treatment pathways for disorders such as Rasmussen's encephalitis and Guillain Barre Syndrome.

In April 2002, Graham became a Forensic Biologist for the London laboratory of the Forensic Science Service (then part of the Home Office). During this time, Graham reported hundreds of cases ranging from volume crime such as 'taking without consent' and muggings through to sexual offences, homicides and terrorism cases. He developed particular expertise with interpreting DNA profiling results from firearms. He has forensic expertise in Body Fluid evidence, DNA profiling, Bloodstain Pattern Analysis and Clothing Damage Analysis. He is also an expert witness with court-going experience.

In 2007, Graham became a Lecturer in Forensic Science in the School of Applied Sciences, where he lectures in Crime Scene Investigations, Forensic Investigations and Forensic Science and the Law. He also provides workshops on Bloodstain Pattern Analysis (BPA). Graham also developed and is course leader for the MSc Forensic Science suite of courses.

Graham has extensive research interests, but his main research strand is Forensic RNA Analysis for body fluid identification and time-since-deposition of stains – managing a large team working in this field and has extensive publications and conference presentations in this field. He also has research interests in clothing damage analysis and bloodstain pattern analysis.

In his professional capacity, Graham also acts as a Consultant Forensic Biologist for a number of organisations; including a governmental organisation and an overseas company. He is also a reporting forensic scientist on an ad hoc basis for various organisations, providing reports for both the prosecution and the defence. He is extremely experienced in case work, having examined thousands of items for body fluids, DNA, BPA, and clothing damage. As a predominantly defence expert witness, he currently averages about 15-20 cases per year.

Research and Scholarship

Previous Research

Investigating the auto-immune aspects of epilepsy, such as that in Rasmussen's Encephalitis, Guillian-Barre Syndrome and Systemic Lupus Erythematosus (SLE). This research was also looking to improve therapy for infection induced seizures, such as those exhibited in patients with Falciparum Malaria.

Current Research

I am currently carrying out research in to:

  • Forensic messenger RNA analysis for body fluid identification (BFID)
  • Forensic micro RNA analysis for body fluid identification
  • Developing strategies for the interpretation of miRNA BFID results
  • Developing optimal DNA recovery methods for various surfaces
  • Developing strategies for RNA based stain age determination
  • Clothing damage analysis
  • Bloodstain pattern analysis

Publications and Other Research Outputs

2016

Jung, S., Cho, S., Antunes, J., Gomes, I., Uchimoto, M., Oh, Y., Giacomo, L., Schneider, P., Park, M., van der Meer, D., Williams, G., McCord, B., Ahn, H., Choi, D., Lee, Y., Lee, S. and Lee, H. (2016) ‘A collaborative exercise on DNA methylation-based body fluid typingElectrophoresis , 37 (21), pp. 2759-2766. ISSN 0173-0835

2015

Bexon, K. and Williams, G. (2015) ‘Characterising the fluctuation of microRNA expression throughout a full menstrual cycleForensic Science International: Genetics Supplement Series , 5, pp. 264-266. ISSN 1875-1768

Bexon, K. and Williams, G. (2015) ‘Characterising the fluctuation of microRNA expression throughout a full menstrual cycleForensic Science International: Genetics Supplement Series , 5, pp. 264-266. ISSN 1875-1768

van der Meer, D. and Williams, G. (2015) ‘Performing Body Fluid Identification using a MicroRNA Multiplex with Capillary Electrophoresis’. In: 26th Congress of the International Society for Forensic Genetics, 31st August - 5th September 2015, Poland

Bexon, K. and Williams, G. (2015) ‘Body Fluid Specific Micro-RNA Markers: Characterising the Fluctuation of Expression in Vaginal Material when Analysed Over a Full Menstrual Cycle’. In: 26th Congress of the International Society for Forensic Genetics, 31st August - 5th September 2015, Poland

Rada, N., van der Meer, D., Uchimoto, M. and Williams, G. (2015) ‘Methylation profiling of ELOVL2 for age prediction in forensic investigations using SNaPshot’. In: 7th European Academy of Forensic Science Conference, 6th - 11th September 2015, Prague

Bexon, K. and Williams, G. (2015) ‘Body Fluid Specific Micro-RNA Markers: Characterising the Fluctuation of Expression in Vaginal Material when Analysed Over a Full Menstrual Cycle’. In: 9th ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Individualized Medicine, 22nd - 26th June 2015, Croatia

van der Meer, D. and Williams, G. (2015) ‘On combining microRNA analysis with DNA profiling in a single stream process’. In: American Academy of Forensic Sciences 67th Annual Meeting, Orlando, FL, USA, 16th - 21st February 2015, Orlando, FL, USA , p. 935

Stewart, L., Evans, N., Bexon, K., van der Meer, D. and Williams, G. (2015) ‘Differentiating between monozygotic twins through DNA methylation specific high resolution melt curve analysisAnalytical Biochemistry . ISSN 0003-2697

Dunnett, H., Williams, G. and Van der Meer, D. (2015) ‘Evaluation of Stem-Loop Reverse Transcription and Poly-A Tail Extension in MicroRNA Analysis of Body FluidsMicroRNA , 4. ISSN 2211-5366

2014

Bexon, K. and Williams, G. (2014) ‘Characterising changes in expression of body fluid specific microRNA markers in vaginal material over a 31 day period’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece

Stewart, L., Evans, N., Bexon, K., van der Meer, D. and Williams, G. (2014) ‘Differentiating between monozygotic twins through methylation specific high resolution melt curve analysis’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece

van der Meer, D., Uchimoto, M. and Williams, G. (2014) ‘Combining microRNA analysis with DNA profiling in a single stream process’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece

Uchimoto, M., Coult, N. and Williams, G. (2014) ‘Characterisation of OFMIR-205,MIR-451 and RNU44 in blood and saliva samples’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece

Williams, G (2014) ‘Latest Developments in Forensic Applications in MicroRNA Analysis’. In: Forensic Europe Expo 2014, 29th - 30th April 2014, London, UK

2013

Williams, G., Uchimoto, M., Coult, N., World, D. and Beasley, E. (2013) ‘Body fluid mixtures; resolution using forensic microRNA analysisForensic Science International: Genetics Supplement Series , 4 (1), pp. 292-293. ISSN 1875-1768

Williams, G., Uchimoto, M., Coult, N., World, D., Beasley, E. and Avenell, P. (2013) ‘Characterisation of body fluid specific microRNA markers by capillary electrophoresisForensic Science International: Genetics Supplement Series , 4 (1), pp. 274-275. ISSN 1875-1768

Williams, G., Connolly, J., Omelia, E., Beasley, E. and Gaduzo, D. (2013) ‘Characterising degradation profiles of RNA molecules within blood stains: Pilot studies’. In: Advances in Temporal Forensic Investigations, 4th-5th November 2013, Huddersfield, UK

Bostock, E., Parkes, G. and Williams, G. (2013) ‘A novel method for the analysis of slash cuts to clothingJournal of Forensic Research . ISSN 2157-7145

Williams, G., Uchimoto, M., Coult, N., World, D. and Beasley, E. (2013) ‘Body fluid mixtures; resolution using forensic microRNA analysis’. In: The 25th World Congress of the International Society for Forensic Genetics, 2nd-7th September 2013, Melbourne, Australia , p. 172

Williams, G., Uchimoto, M., Coult, N., World, D., Beasley, E. and Avenell, P. (2013) ‘Characterisation of body fluid specific microRNA markers by capillary electrophoresis’. In: The 25th World Congress of the International Society for Forensic Genetics, 2nd-7th September 2013, Melbourne, Australia , p. 171

Williams, G., Pandre, M., Ahmed, W., Beasley, E. and Omelia, E. (2013) ‘Evaluation of low trace DNA recovery techniques from ridged surfacesJournal of Forensic Research . ISSN 2157-7145

Uchimoto, M., Beasley, E., Coult, N., Omelia, E., World, D. and Williams, G. (2013) ‘Considering the effect of stem-loop reverse transcription and quantitative PCR analysis of blood and saliva specific microRNA markers upon mixed body fluid stainsForensic Science International: Genetics , 7 (4), pp. 418-421. ISSN 1872-4973

Van der Meer, D., Uchimoto, M. and Williams, G. (2013) ‘Simultaneous analysis of microRNA and DNA for determining the body fluid origin of DNA profilesJournal of Forensic Sciences , 58 (4), pp. 967-971. ISSN 0022-1198

Omelia, E., Uchimoto, M. and Williams, G. (2013) ‘Quantitative PCR analysis of blood and saliva specific microRNA markers following DNA extractionAnalytical Biochemistry , 435, pp. 120-122. ISSN 0003-2697

Williams, G (2013) ‘Capillary electrophoretic analysis of body fluid specific microRNA markers in order to multiplex with STR kits’. In: European Forensic DNA Working Group Meeting, 19th - 21st March 2013, Lisbon, Portugal

2012

Coult, N., Uchimoto, M. and Williams, G. (2012) ‘Forensic MicroRNA (miRNA) Analysis of Skin Specific Markers’. In: Forensic Science Society Inaugrural Postgraduate Research Symposium, 10th November 2012, Coventry, UK

Williams, G. and Haider, I. (2012) ‘Differentiating Between Genuine Damage and Falsified Damage to a Garment Following an Alleged Sexual AssaultJournal of Forensic Sciences , 57 (6), pp. 1634-1636. ISSN 0022-1198

Uchimoto, M., Van der Meer, D. and Williams, G. (2012) ‘Single channel simultaneous analysis of DNA and microRNA’. In: 21st International Symposium on the Forensic Sciences of the Australian and New Zealand Forensic Science Society, 23rd September 2012 - 27th September 2012, Hobart, Tasmania, New Zealand

Williams, G (2012) Identification and Resolution of Capability Gaps in Forensic Science Doctoral thesis, University of Huddersfield.

Bexon, K. and Williams, G. (2012) ‘Evaluating the effect of multiple displacement amplification upon low-level multiple source DNA profilesInternational Journal of Criminal Investigation , 2 (2), pp. 103-110. ISSN 2247-0271

Williams, G (2012) ‘Single Channel Simultaneous Analysis of DNA and MicroRNA’. In: Proceedings of the American Academy of Forensic Sciences. Atlanta, Georgia, USA: American Academy of Forensic Sciences AAFS. p. 34.

Connolly, J. and Williams, G. (2012) ‘The Use of Forensic Messenger RNA (mRNA) Analysis to Determine Stain Age’. In: Proceedings of the American Academy of Forensic Sciences Annual Meeting. Atlanta, Georgia, USA: American Academy of Forensic Sciences. p. 320.

2011

Connolly, J. and Williams, G. (2011) ‘Evaluating an MRNA based body fluid identification test using sybr green fluorescent dye and real-time PCRInternational Journal of Criminal Investigation , 1 (4), pp. 177-185. ISSN 2247-0271

Williams, G (2011) ‘Forensic Applications of Whole Genome AmplificationInternational Journal of Criminal Investigation , 1 (3), pp. 123-135. ISSN 2247-0271

Uchimoto, M., Clarke, D. and Williams, G. (2011) ‘A novel method for the simultaneous co-isolation of DNA and mRNA for forensic casework samples’. In: Proceedings of the 7th National FORREST Conference 2011(FORensic RESearch and Teaching). Nottingham, UK: The Higher Education Academy UK Physical Sciences Centre in conjunction with Nottingham Trent University. p. 30.

Connolly, J., Clarke, D. and Williams, G. (2011) ‘The use of forensic mRNA analysis to determine stain age’. In: Proceedings of the 7th National FORREST Conference 2011(FORensic RESearch and Teaching). Nottingham, UK: The Higher Education Academy UK Physical Sciences Centre in conjunction with Nottingham Trent University. p. 26.

2010

Connelly, J., Williams, G. and Clarke, D. (2010) ‘The development of an mRNA body fluid identification test utilising real-time PCR and the SYBR green fluorescent dye’. In: 6th National FORREST Conference 2010, 29th - 30th June 2010, Coventry, UK

Williams, G. and Clarke, D. (2010) ‘The use of multiple displacement amplification upon DNA recovered from discharged cartridge casings and shotgun shells’. In: 6th National FORREST Conference 2010, 29th - 30th June 2010, Coventry, UK

2005

Lang, B., Newbold, C., Williams, G., Peshu, N., Marsh, K. and Newton, C. (2005) ‘Antibodies to Voltage-Gated calcium channels in children with Falciparum MalariaThe Journal of Infectious Diseases , 191 (1), pp. 117-121. ISSN 0022-1899

2002

Palace, J., Williams, G., Lang, B. and Vincent, A. (2002) ‘Antibodies to voltage gated potassium channels in encephalitisJournal of Neurology, Neurosurgery and Psychiatry , 73 (2), p. 234. ISSN 0022-3050

Esteem

Professional Bodies

  • Professional Member of the Forensic Science Society
  • Member of the International Society of Forensic Genetics
  • Member of the Home Office Centre for Applied Sciences and Technology DNA Expert Community
  • Member of the International Association of Bloodstain Pattern Analysts (IABPA)
  • Member of the Society of Biology
  • Chartered Biologist
  • Fellow of the Higher Education Academy

Research Degree Supervision

Graham is currently supervising post-graduate research in the following topics:-

  • Quantitative mRNA analysis to identify body fluids using, determining stain ages and post-mortem intervals
  • Development of a single channel dual extraction and analysis of DNA/microRNA protocol.
  • Clothing Damage Analysis

Postgraduate research opportunities with Dr Graham Williams

2017-18

PhD