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Kofi is a Lecturer in Pharmaceutics at the University of Huddersfield and was appointed to this role in 2014. Kofi completed his PhD at the Medway School of Pharmacy, University of Kent in 2012. His PhD was an Industrial CASE studentship with the University and the polymer company Colorcon. His research work which specifically focused on the development of an in-vitro testing method to investigate drug release from hypromellose matrix tablets under fed and fasted conditions was supervised by Professor Ali Nokhodchi and Dr Ali Rajabi-Siahboomi. Following the successful completion of his PhD, Kofi was employed by the University of Huddersfield in 2012 as a Research Assistant then as a Research Fellow before taking up the post of a lectureship. Kofi also became a Fellow of the Higher Education Academy in 2014. Kofi successfully collaborates with other universities and several pharmaceutical industries.
Kofis research looks at improving the solubility of poorly soluble drugs using various particle engineering techniques in the view of improving bioavailability and other physicochemical and physicomechanical properties.
As food administration affects the bioavailability of oral dosage forms of a drug, Kofis research also entails the investigation into different parameters that combine to determine a robust formulation of a drug, an essential aspect of drug delivery. This also encompasses method developments for discriminating hydrophilic matrices under fasting and fed conditions.
Ramirez, M., David, S., Schwalbe, C., Asare-Addo, K., Conway, B. and Timmins, P. (2017) ‘Crystal packing arrangement, chain conformation, and physicochemical properties of gemfibrozil amine salts’ Crystal Growth and Design , 17 (7), pp. 3743-3750. ISSN 1528-7483
Nep, E., Asare-Addo, K., Ngwuluka, N., Conway, B. and Smith, A. (2016) ‘Evaluation of sesamum gum as an excipient in matrix tablets’ British Journal of Pharmacy , 1 (1). ISSN 2058-8356
Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions’ Colloids and Surfaces B: Biointerfaces , 146, pp. 841-851. ISSN 0927-7765
Kelidari, H., Saeedi, M., Hajheydari, Z., Akbari, J., Morteza-Semnani, K., Akhtari, J., Valizadeh, H., Asare-Addo, K. and Nokhodchi, A. (2016) ‘Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial’ Colloids and Surfaces B: Biointerfaces , 146, pp. 47-53. ISSN 0927-7765
Akbari, J., Saeedi, M., Morteza-Semnani, K., Rostamkalaei, S., Asadi, M., Asare-Addo, K. and Nokhodchi, A. (2016) ‘The design of naproxen solid lipid nanoparticles to target skin layers’ Colloids and Surfaces B: Biointerfaces , 145, pp. 626-633. ISSN 0927-7765
Asare-Addo, K., �upuk, E., Mahdi, M., Adebisi, A., Nep, E., Conway, B., Kaialy, W., Al-Hamidi, H. and Nokhodchi, A. (2016) ‘Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength’ Colloids and Surfaces B: Biointerfaces , 143, pp. 481-489. ISSN 0927-7765
Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine’ Powder Technology , 292, pp. 342-350. ISSN 00325910
Nep, E., Asare-Addo, K., Ghori, M., Conway, B. and Smith, A. (2015) ‘Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour’ International Journal of Pharmaceutics , 496 (2), pp. 689-698. ISSN 03785173
Adebisi, A., Conway, B. and Asare-Addo, K. (2015) ‘The influence of fillers on theophylline release from clay matrices’ American Journal of Pharmacological Sciences , 3 (5), pp. 120-125. ISSN 2327-6711
Nokhodchi, A., Palmer, D., Asare-Addo, K., Levina, M. and Rajabi-Siahboomi, A. (2015) ‘Application of Polymer Combinations in Extended Release Hydrophilic Matrices’. In: Handbook of Polymers for Pharmaceutical Technologies. : Wiley. pp. 23-50. ISBN 978-1-119-04134-4
Asare-Addo, K., Adebisi, A. and Nokhodchi, A. (2015) ‘Agitation Sequence and Ionic Strength on In-Vitro Drug Release from Hypromellose The Influence of Compaction Force’ International Journal of Basic Medical Sciences and Pharmacy , 5 (1). ISSN 2049-4963
Asare-Addo, K., �upuk, E., Al-Hamidi, H., Owusu-Ware, S., Nokhodchi, A. and Conway, B. (2015) ‘Triboelectrification and dissolution property enhancements of solid dispersions’ International Journal of Pharmaceutics , 485 (1/2), pp. 306-316. ISSN 03785173
Laity, P., Asare-Addo, K., Sweeney, F., �upuk, E. and Conway, B. (2015) ‘Using small-angle X-ray scattering to investigate the compaction behaviour of a granulated clay’ Applied Clay Science , 108, pp. 149-164. ISSN 01691317
Nokhodchi, A., Homayouni, A., Araya, R., Kaialy, W., Obeidat, W. and Asare-Addo, K. (2015) ‘Crystal engineering of ibuprofen using starch derivatives in crystallization medium to produce promising ibuprofen with improved pharmaceutical performance’ RSC Advances , 5 (57), pp. 46119-46131. ISSN 2046-2069
Al-Hamidi, H., Asare-Addo, K., Desai, S., Kitson, M. and Nokhodchi, A. (2014) ‘The dissolution and solid-state behaviours of coground ibuprofenglucosamine HCl’ Drug Development and Industrial Pharmacy , pp. 1-11. ISSN 0363-9045
Nokhodchi, A. and Asare-Addo, K. (2014) ‘Drug release from matrix tablets: physiological parameters and the effect of food’ Expert Opinion on Drug Delivery , 11 (9), pp. 1401-1418. ISSN 1742-5247
Kaialy, W., Emami, P., Asare-Addo, K., Shojaee, S. and Nokhodchi, A. (2014) ‘Psyllium: a promising polymer for sustained release formulations in combination with HPMC polymers’ Pharmaceutical Development and Technology , 19 (3), pp. 269-277. ISSN 1083-7450
�upuk, E., Ghori, M., Asare-Addo, K., Laity, P., Panchmatia, P. and Conway, B. (2013) ‘The influence of salt formation on electrostatic and compression properties of flurbiprofen salts’ International Journal of Pharmaceutics , 458 (1), pp. 118-127. ISSN 0378-5173
Asare-Addo, K., Conway, B., Hajamohaideen, M., Kaialy, W., Nokhodchi, A. and Larhrib, E. (2013) ‘Aqueous And Hydro-Alcoholic Media Effects On Polyols’ Colloids and Surfaces B: Biointerfaces , 111, pp. 24-29. ISSN 0927-7765
Asare-Addo, K., Conway, B., Larhrib, H., Levina, M., Rajabi-Siahboomi, A., Tetteh, J., Boateng, J. and Nokhodchi, A. (2013) ‘The effect of pH and ionic strength of dissolution media on in-vitro release of two model drugs of different solubilities from HPMC matrices’ Colloids and Surfaces B: Biointerfaces , 111, pp. 384-391. ISSN 0927-7765
Asare-Addo, K., Mahdi, M. and Smith, A. (2013) ‘Development of modified release paediatric liquids’. In: 5th EuPFI Conference, 18th-19th Spain 2013, Barcelona, Spain , pp. 31-32
Shojaee, S., Asare-Addo, K., Kaialy, W., Nokhodchi, A. and Cumming, I. (2013) ‘An Investigation into the Stabilization of Diltiazem HCl Release from Matrices Made from Aged Polyox Powders’ AAPS PharmSciTech . ISSN 1530-9932
Asare-Addo, K., Kaialy, W., Levina, M., Rajabi-Siahboomi, A., Ghori, M., �upuk, E., Laity, P., Conway, B. and Nokhodchi, A. (2013) ‘The influence of agitation sequence and ionic strength on in vitro drug release from hypromellose (E4M and K4M) ER matrices--the use of the USP III apparatus.’ Colloids and Surfaces B: Biointerfaces , 104, pp. 54-60. ISSN 0927-7765
Asare-Addo, K., Kaialy, W., Levina, M., Rajabi-Siahboomi, A., Ghori, M., �upuk, E., Laity, P., Conway, B. and Nokhodchi, A. (2013) ‘The Influence of Agitation Sequence and Ionic Strength on in-vitro Drug Release from Hypromellose (E4 M and K4 M) ER Matrices - The use of the USP III Apparatus’ Colloids and Surfaces B: Biointerfaces , 104, pp. 54-60. ISSN 0927-7765
Al-Hamidi, H., Edwards, A., Douroumis, D., Asare-Addo, K., Nayebi, A., Reyhani-Rad, S., Mahmoudi, J. and Nokhodchi, A. (2013) ‘Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling’ Colloids and Surfaces B: Biointerfaces , 103, pp. 189-199. ISSN 09277765
Nokhodchi, A., Raja, S., Patel, P. and Asare-Addo, K. (2012) ‘The Role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems’ BioImpacts , 2 (4). ISSN 2228-5652
Asare-Addo, K., Levina, M., Rajabi-Siahboomi, A. and Nokhodchi, A. (2011) ‘Effect of ionic strength and pH of dissolution media on theophylline release from hypromellose matrix tabletsApparatus USP III, simulated fasted and fed conditions’ Carbohydrate Polymers , 86 (1), pp. 85-93. ISSN 0144-8617
Siahi-Shadbad, M., Asare-Addo, K., Azizian, K., Hassanzadeh, D. and Nokhodchi, A. (2011) ‘Release Behaviour of Propranolol HCl from Hydrophilic Matrix Tablets Containing Psyllium Powder in Combination with Hydrophilic Polymers’ AAPS PharmSciTech , 12 (4), pp. 1176-1182. ISSN 1530-9932
Asare-Addo, K., Levina, M., Rajabi-Siahboomi, A. and Nokhodchi, A. (2010) ‘Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices: The influence of agitation sequence’ Colloids and Surfaces B: Biointerfaces , 81 (2), pp. 452-460. ISSN 0927-7765
As most drugs are poorly soluble, we utilize various particle engineering techniques in the formation of cocrystals, salts, solid dispersions and the manipulation of crystal habit using novel excipients in improving solubility. The School is well equipped with machines such as XRD, single crystal, DSC, SEM, spray drier and a freeze drier with allows the manufacture and characterization of samples in aiding the understanding of the impact of various parameters on the solid state properties of particles that are engineered.
As the ideal oral solid dosage form is one that achieves zero order release, current research explores the use of novel polymers and smectite clays in tablet matrices and exploring various techniques such as liquisolid systems in the bid to obtain a zero order release. Other physicochemical properties studied include their compaction properties and complex forming abilities (ITC). The tomography machine we have allows us to evaluate the internal structure of our compacts in a non-destructive way.
Enquiries from potential students wishing to further develop above areas are welcomed.