Portrait of Dr Kofi Asare-Addo Dr Kofi Asare-Addo

k.asare-addo@hud.ac.uk | 01484 472360



Biography

Kofi is a Lecturer in Pharmaceutics at the University of Huddersfield and was appointed to this role in 2014. Kofi completed his PhD at the Medway School of Pharmacy, University of Kent in 2012. His PhD was an Industrial CASE studentship with the University and the polymer company Colorcon. His research work which specifically focused on the development of an in-vitro testing method to investigate drug release from hypromellose matrix tablets under fed and fasted conditions was supervised by Professor Ali Nokhodchi and Dr Ali Rajabi-Siahboomi. Following the successful completion of his PhD, Kofi was employed by the University of Huddersfield in 2012 as a Research Assistant then as a Research Fellow before taking up the post of a lectureship. Kofi also became a Fellow of the Higher Education Academy in 2014. Kofi successfully collaborates with other universities and several pharmaceutical industries.

Research and Scholarship

Kofi’s research looks at improving the solubility of poorly soluble drugs using various particle engineering techniques in the view of improving bioavailability and other physicochemical and physicomechanical properties.

As food administration affects the bioavailability of oral dosage forms of a drug, Kofi’s research also entails the investigation into different parameters that combine to determine a robust formulation of a drug, an essential aspect of drug delivery. This also encompasses method developments for discriminating hydrophilic matrices under fasting and fed conditions.

Publications and Other Research Outputs

2017

Ramirez, M., David, S., Schwalbe, C., Asare-Addo, K., Conway, B. and Timmins, P. (2017) ‘Crystal packing arrangement, chain conformation, and physicochemical properties of gemfibrozil amine saltsCrystal Growth and Design , 17 (7), pp. 3743-3750. ISSN 1528-7483

2016

Nep, E., Asare-Addo, K., Ngwuluka, N., Conway, B. and Smith, A. (2016) ‘Evaluation of sesamum gum as an excipient in matrix tabletsBritish Journal of Pharmacy , 1 (1). ISSN 2058-8356

Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersionsColloids and Surfaces B: Biointerfaces , 146, pp. 841-851. ISSN 0927-7765

Kelidari, H., Saeedi, M., Hajheydari, Z., Akbari, J., Morteza-Semnani, K., Akhtari, J., Valizadeh, H., Asare-Addo, K. and Nokhodchi, A. (2016) ‘Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trialColloids and Surfaces B: Biointerfaces , 146, pp. 47-53. ISSN 0927-7765

Akbari, J., Saeedi, M., Morteza-Semnani, K., Rostamkalaei, S., Asadi, M., Asare-Addo, K. and Nokhodchi, A. (2016) ‘The design of naproxen solid lipid nanoparticles to target skin layersColloids and Surfaces B: Biointerfaces , 145, pp. 626-633. ISSN 0927-7765

Asare-Addo, K., �upuk, E., Mahdi, M., Adebisi, A., Nep, E., Conway, B., Kaialy, W., Al-Hamidi, H. and Nokhodchi, A. (2016) ‘Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strengthColloids and Surfaces B: Biointerfaces , 143, pp. 481-489. ISSN 0927-7765

Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepinePowder Technology , 292, pp. 342-350. ISSN 00325910

2015

Nep, E., Asare-Addo, K., Ghori, M., Conway, B. and Smith, A. (2015) ‘Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviourInternational Journal of Pharmaceutics , 496 (2), pp. 689-698. ISSN 03785173

Adebisi, A., Conway, B. and Asare-Addo, K. (2015) ‘The influence of fillers on theophylline release from clay matricesAmerican Journal of Pharmacological Sciences , 3 (5), pp. 120-125. ISSN 2327-6711

Nokhodchi, A., Palmer, D., Asare-Addo, K., Levina, M. and Rajabi-Siahboomi, A. (2015) ‘Application of Polymer Combinations in Extended Release Hydrophilic Matrices’. In: Handbook of Polymers for Pharmaceutical Technologies. : Wiley. pp. 23-50. ISBN 978-1-119-04134-4

Asare-Addo, K., Adebisi, A. and Nokhodchi, A. (2015) ‘Agitation Sequence and Ionic Strength on In-Vitro Drug Release from Hypromellose –The Influence of Compaction ForceInternational Journal of Basic Medical Sciences and Pharmacy , 5 (1). ISSN 2049-4963

Asare-Addo, K., �upuk, E., Al-Hamidi, H., Owusu-Ware, S., Nokhodchi, A. and Conway, B. (2015) ‘Triboelectrification and dissolution property enhancements of solid dispersionsInternational Journal of Pharmaceutics , 485 (1/2), pp. 306-316. ISSN 03785173

Laity, P., Asare-Addo, K., Sweeney, F., �upuk, E. and Conway, B. (2015) ‘Using small-angle X-ray scattering to investigate the compaction behaviour of a granulated clayApplied Clay Science , 108, pp. 149-164. ISSN 01691317

Nokhodchi, A., Homayouni, A., Araya, R., Kaialy, W., Obeidat, W. and Asare-Addo, K. (2015) ‘Crystal engineering of ibuprofen using starch derivatives in crystallization medium to produce promising ibuprofen with improved pharmaceutical performanceRSC Advances , 5 (57), pp. 46119-46131. ISSN 2046-2069

2014

Al-Hamidi, H., Asare-Addo, K., Desai, S., Kitson, M. and Nokhodchi, A. (2014) ‘The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HClDrug Development and Industrial Pharmacy , pp. 1-11. ISSN 0363-9045

Nokhodchi, A. and Asare-Addo, K. (2014) ‘Drug release from matrix tablets: physiological parameters and the effect of foodExpert Opinion on Drug Delivery , 11 (9), pp. 1401-1418. ISSN 1742-5247

Kaialy, W., Emami, P., Asare-Addo, K., Shojaee, S. and Nokhodchi, A. (2014) ‘Psyllium: a promising polymer for sustained release formulations in combination with HPMC polymersPharmaceutical Development and Technology , 19 (3), pp. 269-277. ISSN 1083-7450

2013

�upuk, E., Ghori, M., Asare-Addo, K., Laity, P., Panchmatia, P. and Conway, B. (2013) ‘The influence of salt formation on electrostatic and compression properties of flurbiprofen saltsInternational Journal of Pharmaceutics , 458 (1), pp. 118-127. ISSN 0378-5173

Asare-Addo, K., Conway, B., Hajamohaideen, M., Kaialy, W., Nokhodchi, A. and Larhrib, E. (2013) ‘Aqueous And Hydro-Alcoholic Media Effects On PolyolsColloids and Surfaces B: Biointerfaces , 111, pp. 24-29. ISSN 0927-7765

Asare-Addo, K., Conway, B., Larhrib, H., Levina, M., Rajabi-Siahboomi, A., Tetteh, J., Boateng, J. and Nokhodchi, A. (2013) ‘The effect of pH and ionic strength of dissolution media on in-vitro release of two model drugs of different solubilities from HPMC matricesColloids and Surfaces B: Biointerfaces , 111, pp. 384-391. ISSN 0927-7765

Asare-Addo, K., Mahdi, M. and Smith, A. (2013) ‘Development of modified release paediatric liquids’. In: 5th EuPFI Conference, 18th-19th Spain 2013, Barcelona, Spain , pp. 31-32

Shojaee, S., Asare-Addo, K., Kaialy, W., Nokhodchi, A. and Cumming, I. (2013) ‘An Investigation into the Stabilization of Diltiazem HCl Release from Matrices Made from Aged Polyox PowdersAAPS PharmSciTech . ISSN 1530-9932

Asare-Addo, K., Kaialy, W., Levina, M., Rajabi-Siahboomi, A., Ghori, M., �upuk, E., Laity, P., Conway, B. and Nokhodchi, A. (2013) ‘The influence of agitation sequence and ionic strength on in vitro drug release from hypromellose (E4M and K4M) ER matrices--the use of the USP III apparatus.Colloids and Surfaces B: Biointerfaces , 104, pp. 54-60. ISSN 0927-7765

Asare-Addo, K., Kaialy, W., Levina, M., Rajabi-Siahboomi, A., Ghori, M., �upuk, E., Laity, P., Conway, B. and Nokhodchi, A. (2013) ‘The Influence of Agitation Sequence and Ionic Strength on in-vitro Drug Release from Hypromellose (E4 M and K4 M) ER Matrices - The use of the USP III ApparatusColloids and Surfaces B: Biointerfaces , 104, pp. 54-60. ISSN 0927-7765

Al-Hamidi, H., Edwards, A., Douroumis, D., Asare-Addo, K., Nayebi, A., Reyhani-Rad, S., Mahmoudi, J. and Nokhodchi, A. (2013) ‘Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon millingColloids and Surfaces B: Biointerfaces , 103, pp. 189-199. ISSN 09277765

2012

Nokhodchi, A., Raja, S., Patel, P. and Asare-Addo, K. (2012) ‘The Role of Oral Controlled Release Matrix Tablets in Drug Delivery SystemsBioImpacts , 2 (4). ISSN 2228-5652

2011

Asare-Addo, K., Levina, M., Rajabi-Siahboomi, A. and Nokhodchi, A. (2011) ‘Effect of ionic strength and pH of dissolution media on theophylline release from hypromellose matrix tablets—Apparatus USP III, simulated fasted and fed conditionsCarbohydrate Polymers , 86 (1), pp. 85-93. ISSN 0144-8617

Siahi-Shadbad, M., Asare-Addo, K., Azizian, K., Hassanzadeh, D. and Nokhodchi, A. (2011) ‘Release Behaviour of Propranolol HCl from Hydrophilic Matrix Tablets Containing Psyllium Powder in Combination with Hydrophilic PolymersAAPS PharmSciTech , 12 (4), pp. 1176-1182. ISSN 1530-9932

2010

Asare-Addo, K., Levina, M., Rajabi-Siahboomi, A. and Nokhodchi, A. (2010) ‘Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices: The influence of agitation sequenceColloids and Surfaces B: Biointerfaces , 81 (2), pp. 452-460. ISSN 0927-7765

Research Degree Supervision

Particle engineering

As most drugs are poorly soluble, we utilize various particle engineering techniques in the formation of cocrystals, salts, solid dispersions and the manipulation of crystal habit using novel excipients in improving solubility. The School is well equipped with machines such as XRD, single crystal, DSC, SEM, spray drier and a freeze drier with allows the manufacture and characterization of samples in aiding the understanding of the impact of various parameters on the solid state properties of particles that are engineered.

Oral controlled release formulation

As the ideal oral solid dosage form is one that achieves zero order release, current research explores the use of novel polymers and smectite clays in tablet matrices and exploring various techniques such as liquisolid systems in the bid to obtain a zero order release. Other physicochemical properties studied include their compaction properties and complex forming abilities (ITC). The tomography machine we have allows us to evaluate the internal structure of our compacts in a non-destructive way.

Enquiries from potential students wishing to further develop above areas are welcomed.