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Adeola is a Lecturer in the Department of Pharmacy. She graduated from the University of Ibadan, Ibadan, Nigeria with a degree in Pharmacy and then obtained a Master’s degree in Pharmaceutical Science at Aston University, Birmingham, UK. She was awarded a PhD in 2014 by the University of Huddersfield. Her PhD thesis was titled, “Design of gastro-retentive systems for the eradication of helicobacter-pylori infections in the treatment of peptic ulcer” and was supervised by Professor Barbara Conway. Adeola worked on various research projects and teaching upon completion of her PhD in the Department of Pharmacy prior to her appointment by the University of Huddersfield as a Post-doctoral Research Assistant in May 2015, then Research Fellow in August 2016. She is a Fellow of the Higher Education Academy.
Adeola’s research interests are primarily in the area of targeted drug delivery with emphasis on mucoadhesive and gastroretentive drug delivery systems in the form of surface-modified or conjugated microparticles and nanoparticles to enhance the gastro-retention of delivery systems. In addition, recent research focuses on modification of natural or synthetic polymers to enhance their mucoadhesive and physicochemical properties. Other areas of interest include particle engineering of poorly soluble drugs to enhance their solubility and stability profiles, design of in vitro drug diffusion models and assessing the pharmaceutical applications of natural polymers.
Nep, E., Mahdi, M., Adebisi, A., Dawson, C., Walton, K., Bills, P., Conway, B., Smith, A. and Asare-Addo, K. (2017) ‘The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets’ International Journal of Pharmaceutics , 532 (1), pp. 352-364. ISSN 03785173
Nep, E., Mahdi, M., Adebisi, A., Ngwuluka, N., Conway, B., Smith, A. and Asare-Addo, K. (2017) ‘Hydro-alcoholic media effects on theophylline release from sesamum polysaccharide gum matrices’ Drug Development and Industrial Pharmacy . ISSN 0363-9045
Nokhodchi, A., Al-Hamidi, H., Adebisi, A., Asare-Addo, K. and Maniruzzaman, M. (2017) ‘The use of various organic solvents to tailor the properties of ibuprofenglucosamine HCl solid dispersions’ Chemical Engineering Research and Design , 117, pp. 509-519. ISSN 02638762
Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions’ Colloids and Surfaces B: Biointerfaces , 146, pp. 841-851. ISSN 0927-7765
Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine’ Powder Technology , 292, pp. 342-350. ISSN 00325910
Adebisi, A., Conway, B. and Asare-Addo, K. (2015) ‘The influence of fillers on theophylline release from clay matrices’ American Journal of Pharmacological Sciences , 3 (5), pp. 120-125. ISSN 2327-6711
Asare-Addo, K., Adebisi, A. and Nokhodchi, A. (2015) ‘Agitation Sequence and Ionic Strength on In-Vitro Drug Release from Hypromellose The Influence of Compaction Force’ International Journal of Basic Medical Sciences and Pharmacy , 5 (1). ISSN 2049-4963
Adebisi, A. and Conway, B. (2015) ‘Modification of drug delivery to improve antibiotic targeting to the stomach’ Therapeutic Delivery , 6 (6), pp. 741-762. ISSN 2041-5990
Adebisi, A., Laity, P. and Conway, B. (2015) ‘Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori’ Journal of Pharmacy and Pharmacology , 67 (4), pp. 511-524. ISSN 0022-3573
Adebisi, A (2014) Design of gastro-retentive systems for the eradication of helicobacter - pylori infections in the treatment of peptic ulcer Doctoral thesis, University of Huddersfield.
Adebisi, A. and Conway, B. (2014) ‘Lectin-conjugated microspheres for eradication of Helicobacter pylori infection and interaction with mucus’ International Journal of Pharmaceutics , 470 (1-2), pp. 28-40. ISSN 0378-5173
Adebisi, A. and Conway, B. (2014) ‘Preparation and characterisation of gastroretentive alginate beads for targeting H. pylori’ Journal of Microencapsulation , 31 (1), pp. 58-67. ISSN 0265-2048
Adebisi, A. and Conway, B. (2011) ‘Gastroretentive microparticles for drug delivery applications’ Journal of Microencapsulation , 28 (8), pp. 689-708. ISSN 0265-2048
Drug delivery systems directly targeted to the organs or absorption membrane for local or systemic delivery enhances the therapeutic efficacy of the delivered drug. One of the strategies used in drug targeting is mucoadhesive drug delivery. Mucosal layers are found in various regions of the body including the eyes, respiratory tract, gastrointestinal tract and the reproductive tract. These mucoadhesive devices adhere to mucosal layers maintaining an intimate contact with the surface while delivering its drug contents in a controlled manner for local effect or for transmucosal absorption. This direct delivery offers several advantages such as the ability to directly target local disorders such as infections, thereby enhancing the therapeutic effect, reduction of accumulation of drugs in areas where they are not required and minimising side effects. Current research have been focused on the use of mucoadhesive polymers, which have weak and non–specific interactions with mucosal layers, and in most cases such interactions are inadequate for localization of a drug delivery device to a target mucosal site. Therefore, there is increasing interest in the development of mucoadhesive polymers, which have stronger and more specific (site-specific) interactions with mucosal target sites. The aim of this research is to develop novel mucoadhesive polymers that can be used in the design of targeted buccal, nasal and gastroretentive drug delivery systems for treatment of disorders such as oropharyngeal candidiasis, allergic rhinitis and Helicobacter-pylori infection.
Keywords: Mucoadhesive polymers, site-specific delivery, buccal delivery, nasal delivery, mucus model
Natural materials are playing an increasing role as alternatives to synthetic pharmaceutical excipients. This is due to their biocompatibility, low cost, and relative abundance. These natural polymers are now being widely used in the pharmaceutical industry as polymers in various drug delivery systems. Examples of such polymers include sodium alginate, guar gum, chitosan, gum karaya etc. This project involves the extraction of gums and mucilages from different parts of suitable plant materials and the characterization of the extract. In addition, these polymers will be assessed against commercially available polymers in their native form or with some modification to tailor their use for various pharmaceutical applications.
Keywords: Natural polymers, synthetic polymers, gums, plants, polysaccharides
The use of drug delivery technologies that improve drug pharmacokinetics and facilitate local drug delivery to target tissues can enhance the efficacy of various drug therapies. Drug delivery to target mucosal surfaces such as those of the lungs, GI tract, nose, eye etc. is of great interest however, the viscous, elastic and the sticky nature of mucus present in these target sites make drug delivery challenging as the mucus could trap and clear foreign particles such as conventional drug and gene nanocarriers from these surfaces. Mucus-penetrating particles (MPP) avoids rapid mucus clearance and/or reach the underlying epithelia where the drug is required or absorbed. MPP offer advantages of sustained drug delivery at the mucosal surfaces therefore providing improved efficacy and reduced therapeutic side effects. This is achieved by several methods such as modification of particle surface with polymers such as Pluronic F-127 or by disrupting the mucus barrier with chemicals such as N-acetyl-l-cysteine (NAC). This research aims to develop muco-penetrating particles to enhance delivery of drugs and macromolecules to the GI tract.
Keywords: Drug delivery, Muco-penetrating particles (MPP), nanoparticles, mucolytic
Eligibility: Applicants are expected to hold or expect to gain a minimum of a 2:1 Bachelors degree in Pharmacy, Pharmaceutical science, Material science, Chemistry, Biological sciences or any related discipline
Funding: Applications are welcome from self-funded applicants. Tuition fees: up to date information on University website. Bench fees: £3000 - £8000
Start dates: January, April or September 2018