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Chris joined the Department of Chemical Sciences in October 2016 as a Senior Lecturer in Physical Chemistry. Prior to this he was an Assistant Professor in the Department of Physics at the University of Warwick, where from April 2013 he was the Taught Course Leader of the Integrated Magnetic Resonance Centre for Doctoral Training. The EPSRC funded iMR CDT provides research-led training in all aspects of magnetic resonance to PhD students at 6 UK universities with different specialisms in magnetic resonance. Chris was responsible for organising annual residential training workshops and research conferences for the students, alongside much of the day-to-day running of the CDT. During his time as iMR CDT taught course leader Chris gained FHEA (Fellow the the Higher Education Academy) status, and he is particularly interested in the evidence base for recent changes in UK doctoral education.
Chris read Chemistry at Christ Church (University of Oxford) and completed a doctorate on the effect of radiofrequency magnetic fields on radical pair recombination reactions. He spent two years as a post-doctoral research assistant in the Clarendon Laboratory (Department of Physics) investigating molecular magnet systems whose electron-spin can code information for use in quantum information processing (QIP). In collaboration with colleagues at the University of Manchester, and using the facilities of Oxford’s interdisciplinary Centre for Advanced Electron Spin Resonance (CÆSR) based in the Inorganic Chemistry Laboratory, the team showed that the relaxation times of critical importance for QIP can be significantly improved by optimizing the molecular magnet’s chemical structure. Chris also spent time as a PDRA in Oxford’s Chemistry Department where he worked with Prof. P.J. Hore on a project using both optical spectroscopy and nuclear magnetic resonance to test in vitro the hypothesis that birds rely on radical pair reactions in the retina to detect the direction of the Earth’s magnetic field as a compass during migration. Between 2010 and 2013 Chris was a Stipendiary Lecturer in Physical Chemistry at St Hilda's College, Oxford.
External roles: Committee member and webmaster of the Royal Society of Chemistry ESR spectroscopy group; peer review for RoyalSociety and BBSRC; reviewer for journals including Journal of the American Chemical Society, Analyst, Biology Letters, and Physica Status Solidi.
Chris’ research interests include Electron Paramagnetic Resonance (EPR), Spin Hyperpolarization and Spin Chemistry / Magnetic Field Effects. He is currently investigating methods for optical generation of spin polarization as a means to enhance sensitivity in liquid-state NMR. Working with industry partners Bruker, during his recently completed EPSRC first-grant project Chris was able to achieve a proof of principle demonstration for optically generated NMR sensitivity enhancements arising from the so-called radical-triplet pair mechanism. A key focus of his research group is now to develop these ideas further, with projects to both develop the underlying theory and deliver applications on biochemical systems. In the long term the gains in NMR sensitivity this project offers will have a significant impact in a range of areas, NMR being an indispensable tool within the analytical science arsenal.
Chris has numerous collaborations exploiting EPR spectroscopy including investigations of triplet excitions, viologen multimers, paramagnetic palladium compounds, pharmaceutically relevant degradation products, platinum anticancer compounds, enzyme mechanisms and spin-trapping studies of radical polymerisation. Please contact Chris by email if you would like to discuss a potential collaboration.
Vallotto, C., Williams, H., Murphy, D., Ayres, Z., Edge, R., Newton, M. and Wedge, C. (2017) ‘An Electron Paramagnetic Resonance (EPR) spectroscopy study on the ?-irradiation sterilization of the pharmaceutical excipient l-histidine: Regeneration of the radicals in solution’ International Journal of Pharmaceutics , 533 (1), pp. 315-319. ISSN 0378-5173
Venkatesh, V., Berrocal-Martin, R., Wedge, C., Romero-Canel�n, I., Sanchez-Cano, C., Song, J., Coverdale, J., Zhang, P., Clarkson, G., Habtemariam, A., Magennis, S., Deeth, R. and Sadler, P. (2017) ‘Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes’ Chemical Science , 8 (12), pp. 8271-8278. ISSN 2041-6520
Dale, M. and Wedge, C. (2016) ‘Optically generated hyperpolarization for sensitivity enhancement in solution-state NMR spectroscopy’ Chemical Communications , 52 (90), pp. 13221-13224. ISSN 1359-7345
Venkatesh, V., Wedge, C., Romero-Canel�n, I., Habtemariam, A. and Sadler, P. (2016) ‘Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex’ Dalton Trans. , 45 (33), pp. 13034-13037. ISSN 1477-9226
Troadec, T., Tan, S., Wedge, C., Rourke, J., Unwin, P. and Chaplin, A. (2016) ‘One-Electron Oxidation of [M(PtBu3)2] (M=Pd, Pt): Isolation of Monomeric [Pd(PtBu3)2]+and Redox-Promoted C?H Bond Cyclometalation’ Angewandte Chemie International Edition , 55 (11), pp. 3754-3757. ISSN 1433-7851
Chen, L., Willcock, H., Wedge, C., Hartl, F., Colquhoun, H. and Greenland, B. (2016) ‘Efficient access to conjugated 4,4?-bipyridinium oligomers using the Zincke reaction: synthesis, spectroscopic and electrochemical properties’ Organic & Biomolecular Chemistry , 14 (3), pp. 980-988. ISSN 1477-0520
Dodson, C., Wedge, C., Murakami, M., Maeda, K., Wallace, M. and Hore, P. (2015) ‘Fluorescence-detected magnetic field effects on radical pair reactions from femtolitre volumes’ Chemical Communications , 51 (38), pp. 8023-8026. ISSN 1359-7345
Kaminski, D., Webber, A., Wedge, C., Liu, J., Timco, G., Vitorica-Yrezabal, I., McInnes, E., Winpenny, R. and Ardavan, A. (2014) ‘Quantum spin coherence in halogen-modified Cr7Ni molecular nanomagnets’ Physical Review B , 90 (18). ISSN 1098-0121
Wedge, C., Lau, J., Ferguson, K., Norman, S., Hore, P. and Timmel, C. (2013) ‘Spin-locking in low-frequency reaction yield detected magnetic resonance’ Physical Chemistry Chemical Physics , 15 (38), pp. 16043-16053. ISSN 1463-9076
Wedge, C., Timco, G., Spielberg, E., George, R., Tuna, F., Rigby, S., McInnes, E., Winpenny, R., Blundell, S. and Ardavan, A. (2012) ‘Chemical Engineering of Molecular Qubits’ Physical Review Letters , 108 (10). ISSN 0031-9007
Wedge, C., Rodgers, C., Norman, S., Baker, N., Maeda, K., Henbest, K., Timmel, C. and Hore, P. (2009) ‘Radiofrequency polarization effects in low-field electron paramagnetic resonance’ Physical Chemistry Chemical Physics , 11 (31), p. 6573. ISSN 1463-9076
Rodgers, C., Wedge, C., Norman, S., Kukura, P., Nelson, K., Baker, N., Maeda, K., Henbest, K., Hore, P. and Timmel, C. (2009) ‘Radiofrequency polarization effects in zero-field electron paramagnetic resonance’ Physical Chemistry Chemical Physics , 11 (31), pp. 6569-6572. ISSN 1463-9076
I would be willing to supervise PhD students whose own research interests coincide with my own. I am particularly interested in supervising projects dealing with pharmaceutical EPR, spin-hyperpolarization or chemical magnetic field effects. Please feel free to contact me by e-mail.
Details of any funded studentships or postdoctoral posts will be advertised here when they are available.