Portrait of Dr Dougie Clarke Dr Dougie Clarke

View research degree topics that Dr Dougie Clarke might supervise

d.j.clarke@hud.ac.uk | 01484 473142



Biography

Dougie graduated from the University of Strathclyde in 1985 with a BSc in Biochemistry and subsequently gained a PhD in Biochemical pharmacology /toxicology from the Medical Sciences Institute, University of Dundee. He then worked as a Medical Research Council Post Doctoral Research Fellow in the department of Biochemical Medicine and subsequently in the department of Molecular Pathology at Ninewells Hospital and Medical School, Tayside researching the molecular basis of hereditary diseases (such as congenital jaundice) and metabolism of drugs by liver enzymes. From 1992 to 1998, he was a Lecturer in Molecular Medicine at the University of Dundee's Medical School.

Dougie joined the department in 1998 as a Senior Lecturer and became Head of Biological Sciences & Nutrition in 2006. During his time here the number of biological sciences degrees have tripled (including one of the few medical genetics courses in the UK) and the first postgraduate bioscience masters course was initiated in 2005. In 2008 he led a major restructuring of biological sciences and nutrition in which six new lecturing staff were appointed from RAE5* rated groups to lead medical and food science research teams at Huddersfield. His main academic role is to lead, manage and teach on a suite of ten undergraduate BSc courses and two MSc courses. He is currently engaged on a diverse range of research projects encompassing the medical and biotechnology fields.

At Huddersfield Dougie teaches predominantly on honours and postgraduate level modules which he is module leader of such as Applied Molecular Genetics, Bioinformatics, Molecular and Cellular Toxicology and Biochemical Methods. He is the University's representative for the Higher Education Academy Centre of Bioscience and serves on the several School committees including the Management Committee and School Board.

Away from academia, Dougie enjoys travelling, mountain walking, studying wildlife and photography.

Research and Scholarship

Dougie's research team are currently involved in a diverse range of research projects encompassing the medical and biotechnology fields as follows:
  • Khaled Al Salhen – Functional and molecular characterisation of molybdenum hydroxylases
  • Tracey Cheetham - Characterisation of novel anaerobic cellulytic fungi using molecular genetic techniques
  • Stuart Dent - Characterisation of novel sea anemone toxins (in collaboration with Integrin Advanced Biosystems)
  • Dr Graham Williams - The use of novel methodologies to enhance DNA profiling from firearms and discharged cartridge casings
  • Investigation of genetic mutations in rodenticide resistant rats
  • Characterisation of human mesenchymal stem cells using proteomics

Publications and Other Research Outputs

2015

Gomes, V., Pala, M., Salas, A., �lvarez-Iglesias, V., Amorim, A., G�mez-Carballa, A., Carracedo, �., Clarke, D., Hill, C., Mormina, M., Shaw, M., Dunne, D., Pereira, R., Pereira, V., Prata, M., S�nchez-Diz, P., Rito, T., Soares, P., Gusm�o, L. and Richards, M. (2015) ‘Mosaic maternal ancestry in the Great Lakes region of East AfricaHuman Genetics , 134 (9), pp. 1013-1027. ISSN 0340-6717

2011

Uchimoto, M., Clarke, D. and Williams, G. (2011) ‘A novel method for the simultaneous co-isolation of DNA and mRNA for forensic casework samples’. In: Proceedings of the 7th National FORREST Conference 2011(FORensic RESearch and Teaching). Nottingham, UK: The Higher Education Academy UK Physical Sciences Centre in conjunction with Nottingham Trent University. p. 30.

Connolly, J., Clarke, D. and Williams, G. (2011) ‘The use of forensic mRNA analysis to determine stain age’. In: Proceedings of the 7th National FORREST Conference 2011(FORensic RESearch and Teaching). Nottingham, UK: The Higher Education Academy UK Physical Sciences Centre in conjunction with Nottingham Trent University. p. 26.

Soares, P., Rito, T., Trejaut, J., Mormina, M., Hill, C., Tinkler-Hundal, E., Braid, M., Clarke, D., Loo, J., Thomson, N., Denham, T., Donohue, M., Macaulay, V., Lin, M., Oppenheimer, S. and Richards, M. (2011) ‘Ancient Voyaging and Polynesian OriginsThe American Journal of Human Genetics , 88 (2), pp. 239-247. ISSN 00029297

2010

Connelly, J., Williams, G. and Clarke, D. (2010) ‘The development of an mRNA body fluid identification test utilising real-time PCR and the SYBR green fluorescent dye’. In: 6th National FORREST Conference 2010, 29th - 30th June 2010, Coventry, UK

Williams, G. and Clarke, D. (2010) ‘The use of multiple displacement amplification upon DNA recovered from discharged cartridge casings and shotgun shells’. In: 6th National FORREST Conference 2010, 29th - 30th June 2010, Coventry, UK

2007

Hill, C., Soares, P., Mormina, M., Macaulay, V., Clarke, D., Blumbach, P., Vizuete-Forster, M., Forster, P., Bulbeck, D., Oppenheimer, S. and Richards, M. (2007) ‘A mitochondrial stratigraphy for Island Southeast AsiaAmerican Journal of Human Genetics , 80, pp. 29-43. ISSN 1537-6605

2006

Hill, C., Soares, P., Mormina, M., Macaulay, V., Meehan, W., Blackburn, J., Clarke, D., Raja, J., Ismail, P., Bulbeck, D., Oppenheimer, S. and Richards, M. (2006) ‘Phylogeography and Ethnogenesis of Aboriginal Southeast AsiansMolecular Biology and Evolution , 23 (12), pp. 2480-2491. ISSN 0737-4038

2005

Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D., Meehan, W., Blackburn, J., Semino, O., Scozzari, R., Cruciani, F., Taha, A., Shaari, N., Raja, J., Ismail, P., Zainuddin, Z., Goodwin, W., Bulbeck, D., Bandelt, H., Oppenheimer, S., Torroni, A. and Richards, M. (2005) ‘A Response to Tracing Modern Human OriginsScience , 309 (5743), p. 1995b-1997b. ISSN 0036-8075

Harpending, H., Eswaran, V., Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D. and Meehan, W. (2005) ‘Tracing Modern Human OriginsScience , 309 (5743), p. 1995b-1997. ISSN 0036-8075

Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D., Meehan, W., Blackburn, J., Semino, O., Scozzari, R., Cruciani, F., Taha, A., Shaari, N., Raja, J., Ismail, P., Zainuddin, Z., Goodwin, W., Bulbeck, D., Bandelt, H., Oppenheimer, S., Torroni, A. and Richards, M. (2005) ‘Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomesScience , 308 (5724), pp. 1034-1036. ISSN 0036-8075

Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D. and Meehan, W. (2005) ‘Single, Rapid Coastal Settlement of Asia Revealed by Analysis of Complete Mitochondrial GenomesScience , 308 (5724), pp. 1034-1036. ISSN 0036-8075

2001

Lee, W., McKiernan, P., Beath, S., Preece, M., Baty, D., Kelly, D., Burchell, B. and Clarke, D. (2001) ‘Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancyArchives of Disease in Childhood , 85 (1), pp. 38-42. ISSN 00039888

Esteem

Media Appearances

Dougie’s research on the geographic distribution of rats that have mutations in the vitamin K epoxide reductase gene that make them resistant to poisons has attracted in much media coverage in regional and national newspapers, radio and TV.

Research Degree Supervision

Functional and molecular characterisation of molybdenum hydroxylases

Investigation of genetic mutations in rodenticide resistant rats

Characterisation of human mesenchymal stem cells using proteomics

Use of proteomics in toxicological research

Postgraduate research opportunities with Dr Dougie Clarke

2017-18

PhD