Portrait of Dr Karl Hemming Dr Karl Hemming

View research degree topics that Dr Karl Hemming might supervise

k.hemming@hud.ac.uk | 01484 472188



Biography

First degree: BSc(Hons) Applied Chemistry, University of Salford (1989). PhD: Synthetic Organic Chemistry (Synthesis of Four Membered Ring Nitrogen Heterocycles) supervised by Dr R K Smalley, University of Salford (1993). Postdoctoral work (1993 - 1995): Universities of East Anglia and York with Professor R J K Taylor on the synthesis of polyene natural products, such as vitamin A, using pyrylium heterocycles.

I lectured in organic chemistry at the Universities of Bath (1995 - 1996) and Hertfordshire (1996 - 2001), before being appointed to the staff at the University of Huddersfield in August 2001, where I am currently Reader in Organic Chemistry and Course Leader for Chemical Sciences.

Teaching Areas: foundations of organic chemistry, functional group chemistry, pharmaceutical chemistry for pharmacy students, organic chemistry for forensic sciences, carbonyl chemistry, organic synthesis, techniques of practical organic chemistry.

Other Duties: Year Tutor for Year 2 MChem; Course Leader for Chemistry and Forensic & Analytical Science.

External roles: Secretary and Treasurer of the Royal Society of Chemistry Heterocyclic and Synthesis Group 2008-2011 with responsibility for the organisation of the Grasmere Heterocyclic Symposium 2009 and 2011; board of referees for the journal Tetrahedron; regular reviewer for the Journal of Chemical Research, and reviewer for Journal of Organic Chemistry, Tetrahedron Letters and Organic Letters.

Research and Scholarship

Publications and Other Research Outputs

2017

Hemming, K (2017) ‘The Synthesis and Chemistry of Azolobenzodiazepines’. In: Advances in Heterocyclic Chemistry. : Academic Press. pp. 63-103. ISBN 9780128120927

Hamasharif, M., Smith, O., Curran, C. and Hemming, K. (2017) ‘N-Alkylation and Aminohydroxylation of 2-Azidobenzenesulfonamide gives a Pyrrolobenzothiadiazepine precursor whereas attempted N-Alkylation of 2-Azidobenzamide gives Benzotriazinones and QuinazolinonesACS Omega , 2 (3), pp. 1222-1231. ISSN 2470-1343

2016

Hemming, K., Blackburn, J., Molyneux, G., Pitard, A., Rice, C., Page, M., Afshinjavid, S., Javid, F., Coles, S. and Horton, P. (2016) ‘Synthesis, Conformation and Antiproliferative Activity of Isothiazoloisoxazole 1,1-dioxidesOrganic and Biomolecular Chemistry , 14, pp. 2134-2144. ISSN 1477-0539

2015

Hemming, K., Jamshaid, F. and Khan, M. (2015) ‘2-Methylsulfanylbenzo[f]isoquinolineMolbank , 2015 (M860), pp. 1-5. ISSN 1422-8559

2014

Hemming, K (2014) ‘Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-BenzodiazepinesMolecules , 19 (10), pp. 16737-16756. ISSN 1420-3049

Hemming, K., Jamshaid, F. and Chambers, C. (2014) ‘Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-BenzodiazepinesMolecules , 19 (10), pp. 16737-16756. ISSN 1420-3049

Hemming, K., Chambers, C., Hamasharif, M., Jo�oa, H., Khan, M., Patel, N., Airley, R. and Day, S. (2014) ‘Azide based routes to tetrazolo and oxadiazolo derivatives of pyrrolobenzodiazepines and pyrrolobenzothiadiazepinesTetrahedron , 70 (40), pp. 7306-7317. ISSN 0040-4020

Ward, R. and Hemming, K. (2014) ‘Ethane-beta-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent RatsAlcoholoism and Drug Dependence , 2 (2), p. 150. ISSN 2329-6488

2013

Khan, M., Pitard, A., O'Gorman, P. and Hemming, K. (2013) ‘1,2,4-Oxadiazoles from cycloreversions of oxadiazabicyclo[3.2.0]heptenes: 1-azetines as thiocyanate equivalentsTetrahedron , 69 (4), pp. 1279-1284. ISSN 0040-4020

2012

Hemming, K., Kondakal, V. and Qamar, M. (2012) ‘The synthesis of hydroxy-pyrrolizidines and indolizidines from cyclopropenones: towards hyacinthacines, australines and jenamidinesTetrahedron Letters , 53 (32), pp. 4100-4130. ISSN 0040-4039

Hemming, K., Kondakal, V. and Qamar, M. (2012) ‘The synthesis of hydroxy-pyrrolizidines and indolizidines from cyclopropenones: towards hyacinthacines, australines and jenamidinesTetrahedron Letters , 53 (32), pp. 4100-4103. ISSN 0040-4039

Hemming, K., Khan, M., Kondakal, V., Rice, C., Pitard, A. and Qamar, M. (2012) ‘Pyridines from azabicyclo[3.2.0]hept-2-en-4-ones through a proposed azacyclopentadienoneOrganic Letters , 14 (1), pp. 126-129. ISSN 15237060

2011

Hemming, K (2011) ‘Heterocyclic chemistryAnnual Reports Section B Organic Chemistry , 107 (1), pp. 118-137. ISSN 0069-3039

Ward, R., Lallemand, F., de Witte, P., Chrichton, R., Piette, J., Tipton, K., Hemming, K., Pitard, A., Page, M., Corte, L., Taylor, D. and Dexter, D. (2011) ‘Anti-inflammatory actions of a taurine analogue - ethane beta-sultamBiochemical Pharmacology , 81 (6), pp. 743-751. ISSN 0006-2952

2010

Hemming, K (2010) ‘Heterocyclic ChemistryAnnual Reports on the Progress of Chemistry Section B , 106, pp. 136-155. ISSN 0069-3030

Hemming, K (2010) ‘Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepinesTetrahedron Letters , 51 (37), pp. 4859-4861. ISSN 0040-4039

2009

Patel, N., Chambers, C. and Hemming, K. (2009) ‘The synthesis of benzothiadiazines, benzothiadiazepines and benzothiadiazocines from intramolecular azide reactions and iodocyclisationsSynlett , 2009 (18), pp. 3043-3047. ISSN 09365214

Hemming, K (2009) ‘Heterocyclic chemistryAnnual Reports Section "B" (Organic Chemistry) , 105, pp. 129-149. ISSN 00693030

2008

O�Gorman, P., Chen, T., Cross, H., Naeem, S., Pitard, A., Qamar, M. and Hemming, K. (2008) ‘A new and simple method for the synthesis of highly functionalised pyrrolizidines, indolizidines and pyrroloazepinesTetrahedron Letters , 49 (44), pp. 6316-6319. ISSN 0040-4039

Waters, L., Naz, S. and Hemming, K. (2008) ‘Calorimetric investigations of the hydrolytic degradation for a series of ?-sultamsJournal of Thermal Analysis and Calorimetry , 93 (2), pp. 339-342. ISSN 14182874

Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2008) ‘An activated sulfonylating agent that undergoes general base-catalyzed hydrolysis by amines in preference to aminolysisThe Journal of Organic Chemistry , 73 (12), pp. 4504-4512. ISSN 00223263

Hemming, K (2008) ‘1,2,4-Oxadiazoles’. In: Comprehensive Heterocyclic Chemistry III. London, UK: Elsevier. pp. 243-314. ISBN 0-08-044991-3

Hemming, K (2008) ‘Bicyclic 6-6 systems: five or more heteroatoms’. In: Comprehensive Heterocyclic Chemistry III. London, UK: Elsevier. pp. 1093-1134. ISBN 0-08-044991-3

2007

Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2007) ‘Reactivity and selectivity in the inhibition of elastase by 3-oxo-?-sultams and in their hydrolysisOrganic and Biomolecular Chemistry , 5 (24), pp. 3993-4000. ISSN 1477-0539

2006

Hemming, K., O'Gorman, P. and Page, M. (2006) ‘The synthesis of azabicyclo[4.2.1]nonenes by the addition of a cyclopropenone to 4-vinyl substituted 1-azetines-isomers of the homotropane nucleusTetrahedron Letters , 47, pp. 425-428. ISSN 0040-4039

2005

Loukou, C., Hemming, K., Patel, N. and Foucher, V. (2005) ‘The synthesis of 1,2,5-benzothiadiazepine 1,1-dioxides from 1,2-thiazine 1-oxidesJournal of Sulfur Chemistry , 26 (6), pp. 455-479. ISSN 1741-5993

Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2005) ‘Competitive endo- and exo-cyclic C-N fission in the hydrolysis of N-aroyl ?-lactamsCanadian Journal of Chemistry , 83 (9), pp. 1432-1439. ISSN 1480-3291

Hemming, K. and Loukou, C. (2005) ‘Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides - sulfonamide analogues of the 1,4-benzodiazepinesJournal of chemical research (1), pp. 1-12. ISSN 1747-5198

Tsang, W., Ahmed, N., Harding, L., Hemming, K., Laws, A. and Page, M. (2005) ‘Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultamsJournal of the American Chemical Society , 127 (25), pp. 8946-8947. ISSN 1520-5126

2004

Hemming, K. and Loukou, C. (2004) ‘The synthesis of bicyclic 1,2,3,4-tetrahydro-1,4-benzodiazepin-5-ones from 2-(o-nitrobenzyl)-1,2-thiazine-1-oxide precursorsTetrahedron , 60, pp. 3349-3357. ISSN 0040-4020

Hemming, K., Loukou, C., Elkatip, S. and Smalley, R. (2004) ‘The First aza-Wittig Reaction Involving a non-Cumulated Sulfoxy GroupSynlett (1), pp. 101-105. ISSN 09365214

Hemming, K. and Patel, N. (2004) ‘The synthesis of pyrrolo[1,2,b][1,2,5]benzothiadiazepines from 1,2-thiazine 1-oxides-sulfonamide analogues of the pyrrolobenzodiazepine antitumour natural productsTetrahedron Letters , 45, pp. 7553-7556. ISSN 0040-4039

2003

Hemming, K (2003) ‘1,2,4-oxadiazoles’. In: Science of Synthesis: Houben-Weyl Methods of Molecular Transformations. Stuttgart, Germany: Thieme. pp. 1-56. ISBN 9780865779440

2001

Hemming, K (2001) ‘Recent developments in the synthesis, chemistry and applications of the fully unsaturated 1,2,4-oxadiazolesJournal of chemical research , 2001 (6), pp. 209-218. ISSN 1747-5198

2000

Anwar, B., Grimsey, P., Hemming, K., Krajniewski, M. and Loukou, C. (2000) ‘A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepinesTetrahedron Letters , 41 (51), pp. 10107-10110. ISSN 0040-4039

Hemming, K., Morgan, D. and Smalley, R. (2000) ‘A clean and efficient synthesis of 5-(2?-fluoro-2?,3?-dimethylbutan-3?-yl) substituted 1,2,4-oxadiazoles using silver tetrafluoroborate as a fluorodesulfurization reagentJournal of Fluorine Chemistry , 106 (1), pp. 83-86. ISSN 00221139

Hemming, K., Bevan, M., Loukou, C., Patel, S. and Renaudeau, D. (2000) ‘A One-Pot Aza-Wittig Based Solution and Polymer Supported Route to AminesSynlett , 2000 (11), pp. 1565-1568. ISSN 09365214

Esteem

Research Lectures

  • International Congress on Heterocyclic Chemistry: New South Wales (2007); Newfoundland (2009); Glasgow (2011).
  • RSC Meetings: Imperial College (Jan 2011), NorthEast Regional meeting on organic chemistry (April 2011).
  • Invited Lectures: Keele, York, Northumbria

PhD Examiner

  • (UK):York, Strathclyde, Keele, Loughborough, Northumbria, and Greenwich
  • (Non UK): Galway, Dublin, Karolinska Institute (Stockholm, Sweden), Auckland (New Zealand), and Quaid-i-Azam (Islamabad, Pakistan)

Committees

  • Member/Secretary RSC Heterocyclic and Synthesis Group 2008 – 2011
  • Member Committee International Society of Heterocyclic Chemists 2009 – 2011

Reviewer

  • Advisory board of referees, Tetrahedron.
  • Regular reviewer and adjudicator Journal of Chemical Research
  • Regular Reviewer for Journal of Organic Chemistry, Tetrahedron Letters, Organic Letters.

Reviews and Book Chapters

  • Annual Reports on the Progress of Chemistry (2009-2011)
  • Comprehensive Heterocyclic Chemistry 2008

Research Degree Supervision

Synthesis of Biologically Active Indolizidine and Pyrrolizidine Natural Products

This research will be in the area of synthetic organic chemistry and will focus specifically on the synthesis of heterocyclic natural products. The targets of this project are the indolizidine and pyrrolizidine alkaloids. These systems are of interest in the possible treatment of various diseases such as cancer, diabetes and viral infections such as AIDS, and some of them have the potential to function as potent analgesics or as potential treatments for Alzheimer’s disease and other neurological disorders. Examples of such compounds include the well known "poison frog alkaloids".

The Synthesis of the Pyrrolobenzodiazepine Antitumour Antibiotic Natural Products

This research is in the broad areas of synthetic organic chemistry, natural products chemistry and heterocyclic chemistry. The pyrrolobenzodiazepines are a class of naturally occurring alkaloids that have high potency as both antitumour compounds for use in cancer research and as antibiotics with known activity against "superbugs". The target of this project is to synthesise analogues of these systems for screening as antibiotics and against cancer cell lines.

The Synthesis of New Potential Antibiotics

It's well known that "superbugs" with resistance to existing antibiotic drugs are of huge concern to society. The need for potential new antibiotics is therefore high. In this project, which is in the area of synthetic organic chemistry, the target is the synthesis of a series of molecules related to the existing penicillin systems, but with sufficient differences built in to prevent resistance.

Azides as Tools for Synthetic Chemistry and Chemical Biology

This project builds upon our existing published research in this area. Azides are reactive systems that can be used to construct a wide variety of heterocyclic molecules and this project therefore falls in the area of synthetic organic chemistry. The target molecules of this project include completely new heterocycles, but also systems such as mitomycin C, a clinically prescribed antitumour agent. The project is also concerned with the design and synthesis of azides for incorporation into biological systems where they can be used as probes or tags by molecular biologists.

The Synthesis of Heterocycles of Pharmaceutical and Biological Importance

Many molecules used in medicine today are heterocycles. We have a number of projects available in the area of synthetic organic chemistry which focus upon the synthesis of such molecules. These include penicillin type systems, natural products, alkaloids, benzodiazepines and oxadiazoles. The diseases that these molecules target are many, but the list includes anticancer compounds, new antibiotics, new anti-HIV/AIDS drugs and systems targeted at Alzheimer's disease.

Postgraduate research opportunities with Dr Karl Hemming

2017-18

PhD

2018-19

PhD