email@example.com | 01484 473587
I was appointed as a Lecturer in Biological Sciences at Huddersfield in 2008 my main teaching is Cellular and Molecular Biology to MPharm students.
Dunnill, C., Al-Tameemi, W., Collett, A., Haslam, I. and Georgopoulos, N. (2017) ‘A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and its Prevention’ The Oncologist . ISSN 1083-7159
Patten, D., Hussein, E., Davies, S., Humphreys, P. and Collett, A. (2017) ‘Commensal-derived OMVs elicit a mild proinflammatory response in intestinal epithelial cells’ Microbiology , 163 (5), pp. 702-711. ISSN 1465-2080
Patten, D., Leivers, S., Chadha, M., Maqsood, M., Humphreys, P., Laws, A. and Collett, A. (2014) ‘The structure and immunomodulatory activity on intestinal epithelial cells of the EPSs isolated from Lactobacillus helveticus sp. Rosyjski and Lactobacillus acidophilus sp. 5e2.’ Carbohydrate Research , 384, pp. 119-127. ISSN 00086215
Patten, D. and Collett, A. (2013) ‘Exploring the immunomodulatory potential of microbial-associated molecular patterns derived from the enteric bacterial microbiota’ Microbiology , 159 (8), pp. 1535-1544. ISSN 1465-2080
Bannon, C., Davies, P., Collett, A. and Warhurst, G. (2009) ‘Potentiation of flagellin responses in gut epithelial cells by interferon-? is associated with STAT-independent regulation of MyD88 expression’ Biochemical Journal , 423 (1), pp. 119-128. ISSN 0264-6021
Collett, A., Higgs, N., Meritxell, G., Zeef, L., Hayes, A., Salmo, E., Haboubi, N., Iovanna, J., Carlson, G. and Warhurst, G. (2008) ‘Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(?/?) mice’ Inflammatory Bowel Diseases , 14 (5), pp. 620-631. ISSN 10780998
Collett, A (2008) ‘Investigation of Regional Mechanisms Responsible for Poor Oral Absorption in Humans of a Modified Release Preparation of the -Adrenoreceptor Antagonist, 4-Amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): The Rational Use of ex Vivo Intestine to Predict in Vivo Absorption’ Drug Metabolism and Disposition , 36 (1), pp. 87-94. ISSN 00909556
Collett, A., Tanianis-Hughes, J., Carlson, G., Harwood, M. and Warhurst, G. (2005) ‘Comparison of P-glycoprotein-mediated drugdigoxin interactions in Caco-2 with human and rodent intestine: Relevance to in vivo prediction’ European Journal of Pharmaceutical Sciences , 26 (5), pp. 386-393. ISSN 0928-0987
Collett, A., Tanianis-Hughes, J. and Warhurst, G. (2004) ‘Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?’ Biochemical Pharmacology , 68 (4), pp. 783-790. ISSN 0006-2952
Collett, A., Tanianis-Hughes, J., Hallifax, D. and Warhurst, G. (2004) ‘Predicting P-Glycoprotein Effects on Oral Absorption: Correlation of Transport in Caco-2 with Drug Pharmacokinetics in Wild-Type and mdr1a(-/-) Mice in Vivo’ Pharmaceutical Research , 21 (5), pp. 819-826. ISSN 0724-8741
Collett, A., Ramminger, S., Olver, R. and Wilson, S. (2002) ‘Beta-Adrenoceptor-mediated control of apical membrane conductive properties in fetal distal lung epithelia’ American journal of physiology - Lung cellular and molecular physiology , 282 (4), p. L621-L630. ISSN 1040-0605
Baines, D., Ramminger, S., Collett, A., Haddad, J., Best, O., Land, S., Olver, R. and Wilson, S. (2001) ‘Oxygen-evoked Na+ transport in rat fetal distal lung epithelial cells’ The Journal of Physiology , 532 (1), pp. 105-113. ISSN 0022-3751
Haddad, J., Collett, A., Land, S., Olver, R. and Wilson, S. (2001) ‘NF-?B Blockade Reduces the O2-Evoked Rise in Na+ Conductance in Fetal Alveolar Cells’ Biochemical and Biophysical Research Communications , 281 (4), pp. 987-992. ISSN 0006-291X
Land, S. and Collett, A. (2001) ‘Detection of Cl- flux in the apical microenvironment of cultured foetal distal lung epithelial cells’ Journal of Experimental Biology , 204 (4), pp. 785-795. ISSN 0022-0949
McAlroy, H., Ahmed, S., Day, S., Baines, D., Wong, H., Yip, C., Ko, W., Wilson, S. and Collett, A. (2000) ‘Multiple P2Y receptor subtypes in the apical membranes of polarized epithelial cells’ British Journal of Pharmacology , 131 (8), pp. 1651-1658. ISSN 0007-1188
Inglis, S., Collett, A., McAlroy, H., Wilson, S. and Olver, R. (1999) ‘Effect of luminal nucleotides on Cl - secretion and Na + absorption in distal bronchi’ Pflügers Archiv - European Journal of Physiology , 438 (5), pp. 621-627. ISSN 0031-6768
Ramminger, S., Collett, A., Baines, D., Murphie, H., McAlroy, H., Olver, R., Inglis, S. and Wilson, S. (1999) ‘P2Y2 receptor-mediated inhibition of ion transport in distal lung epithelial cells’ British Journal of Pharmacology , 128 (2), pp. 293-300. ISSN 0007-1188
Collett, A., Higgs, N., Sims, E., Rowland, M. and Warhurst, G. (1999) ‘Modulation of the Permeability of H2 Receptor Antagonists Cimetidine and Ranitidine by P-Glycoprotein in Rat Intestine and the Human Colonic Cell Line Caco-21’ The Journal of pharmacology and experimental therapeutics , 288 (1), pp. 178-178. ISSN 0022-3565
Projects in this area will test for potential interactions of newly synthesised biologically active compounds with efflux proteins. This important because in order for drugs to be most effective therapeutically, particularly in the central nervous system, it is advantages if they do not have significant interactions with cellular efflux transporters.
It is becoming increasingly apparent that the normal function of the epithelial cells that line the intestinal mucosa is dependent on their close interaction with the vast and complex micro-flora that resides in the intestine. Most research in this area has concentrated on the effects of individual bacterial species. This project will investigate the role of biofilms which are more realistic of the conditions found in the native intestine.
A vital function of the bodies epithelial barriers is to prevent the access of bacteria into the body thus translocation of bacteria across epithelial cells, particularly those that line the intestine can cause serious disease or death. Projects in this area will investigate the molecular mechanisms by which various bacterial species cross the intestinal epithelia and examine the role of the normal intestinal microflora in preventing this process occurring.