Portrait of Dr Jordi Morral Dr Jordi Morral

j.morral-cardoner@hud.ac.uk | 01484 47



Biography

I graduated with a First Class degree in Pharmacy (MPharm) from the University of Barcelona in 1993 and I was awarded the Degree Extraordinary Award.

I decided to stay at the University of Barcelona to carry out a PhD in Organic and Medicinal Chemistry (Synthesis of tacrine-huperzine A hybrids and huperzine A analogues, with potential utility in the treatment of Alzheimer’s disease) under the co-supervision of Prof Camps and Dr Muñoz-Torrero (1999).

After my PhD I gained five years’ postdoctoral experience at:

  • Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium (2000) with Prof. Herdewijn. Cyclohexene nucleosides as new potent antiviral compounds and antisense oligonucleotides.
  • Laboratory of Medicinal Chemistry, University of Antwerp, Belgium (2001) with Prof. Augustyns and Dr. Wigerinck, Dept. of Medicinal Chemistry and Drug Discovery, Tibotec, Mechelen, Belgium. Bio-affinity resins as absorption model for drug candidates.
  • Chemistry Department at the University of Manchester (2002-2004) with now Prof Micklefield. Exploring the high affinity, kinetically selective binding of RNA over DNA by pyrrolidine-amide oligonucleotide mimics (POM).

After an unexpected change of career working for a while as a Pharmacy Manager for Lloydspharmacy, I am now working as part-time lecturer ((“Drug Synthesis, Metabolism and Analysis” and “Drug Design and Development I”) at the University of Huddersfield. I am an Honorary Research Fellow at the Institute of Cancer Therapeutics, University of Bradford, and work as a part-time pharmacist for Cohens Chemist.

Research and Scholarship

My experience is in the areas of Organic and Medicinal Chemistry and Chemical Biology. I have published widely in these areas and I am co-author of 15 refereed journal articles and one International Patent.

Publications and Other Research Outputs

2016

Campanile, A., Morral, K., Aljammal, M., Felix, O., Elena, T., Shabbir, M., Beadham, I. and Morral-Cardoner, J. (2016) ‘Development of a versatile laboratory experiment to teach the metabolic transformation of hydrolysisBritish Journal of Pharmacy , 1 (1). ISSN 2058-8356

2014

Morral-Cardoner, J (2014) ‘Linking a Pharmaceutical Chemistry Workshop to Pharmacy PracticeScientia Pharmaceutica , 83 (1), pp. 125-142. ISSN 0036-8709

2007

Tan, T., Worthington, R., Pritchard, R., Morral-Cardoner, J. and Micklefield, J. (2007) ‘Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding propertiesOrganic & Biomolecular Chemistry , 5 (2), pp. 239-248. ISSN 14770520

Worthington, R., O'Rourke, A., Morral-Cardoner, J., Tan, T. and Micklefield, J. (2007) ‘Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding propertiesOrganic & Biomolecular Chemistry , 5 (2), pp. 249-259. ISSN 14770520

2004

Tan, T., Hickman, D., Morral-Cardoner, J., Beadham, I. and Micklefield, J. (2004) ‘Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)Chemical Communications (5), pp. 516-517. ISSN 1359-7345

2003

Gu, P., Morral-Cardoner, J., Wang, J., Rozenski, J., Busson, R., Van Aerschot, A., De Clercq, E. and Herdewijn, P. (2003) ‘Synthesis and Biological Evaluation of a Series of New Cyclohexenyl NucleosidesNucleosides, Nucleotides & Nucleic Acids , 22 (5), pp. 845-847. ISSN 1525-7770

Gu, P., Morral-Cardoner, J., Wang, J., Rozenski, J., Busson, R., Van Aerschot, A., De Clercq, E. and Herdewijn, P. (2003) ‘Synthesis and antiviral activity of a series of new cyclohexenyl nucleosidesAntivral Chemistry and Chemotherapy , 14 (1), pp. 31-37. ISSN 0956-3202

Hickman, D., Tan, T., Morral-Cardoner, J., King, P., Cooper, M. and Micklefield, J. (2003) ‘Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)Organic & Biomolecular Chemistry , 1 (19), pp. 3277-3292. ISSN 14770520

2001

Wang, J., Morral-Cardoner, J., Hendrix, C. and Herdewijn, P. (2001) ‘A Straightforward Stereoselective Synthesis of d- and l-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanineThe Journal of Organic Chemistry , 66 (25), pp. 8478-8482. ISSN 00223263

2000

Camps, P., El Achab, R., Morral-Cardoner, J., Mu�oz-Torrero, D., Badia, A., Ba�os, J., Vivas, N., Barril, X., Orozco, M. and Luque, F. (2000) ‘New Tacrine?Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's DiseaseJournal of Medicinal Chemistry , 43 (24), pp. 4657-4666. ISSN 0022-2623

Camps, P., Contreras, J., El Achab, R., Morral-Cardoner, J., Mu�oz-Torrero, D., Font-Bardia, M., Solans, X., Badia, A. and Vivas, N. (2000) ‘New Syntheses of rac-Huperzine A and its rac-7-Ethyl-Derivative. Evaluation of Several Huperzine A Analogues as Acetylcholinesterase InhibitorsTetrahedron , 56 (26), pp. 4541-4553. ISSN 0040-4020

Camps, P., Cusack, B., Mallender, W., El Achab, R., Morral-Cardoner, J., Mu�oz-Torrero, D. and Rosenberry, T. (2000) ‘Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's DiseaseMolecular Pharmacology , 57 (2), pp. 409-417. ISSN 0026-895X

1999

Camps Garcia, P., Mu�oz-Torrero, D., Gorbig, D., Contreras, J., Simon, M., Morral-Cardoner, J., El Achab, R., Badia, A., Ba�os, J. and Vivas, N.(1999) Polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use. 5,965,569.

Camps, P., El Achab, R., G�rbig, D., Morral-Cardoner, J., Mu�oz-Torrero, D., Badia, A., Ba�os, J., Vivas, N., Barril, X., Orozco, M. and Luque, F. (1999) ‘Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine?Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's DiseaseJournal of Medicinal Chemistry , 42 (17), pp. 3227-3242. ISSN 0022-2623

Camps, P., Contreras, J., Morral-Cardoner, J., Mu�oz-Torrero, D., Font-Bardia, M. and Solans, X. (1999) ‘Synthesis of an 11-unsubstituted analogue of (±)-huperzine ATetrahedron , 55 (28), pp. 8481-8496. ISSN 0040-4020

1998

Camps, P., Contreras, J., Font-Bardia, M., Morral-Cardoner, J., Mu�oz-Torrero, D. and Solans, X. (1998) ‘Enantioselective synthesis of tacrine–huperzine A hybrids. Preparative chiral MPLC separation of their racemic mixtures and absolute configuration assignments by X-ray diffraction analysisTetrahedron: Asymmetry , 9 (5), pp. 835-849. ISSN 09574166

Camps, P., Morral-Cardoner, J. and Mu�oz-Torrero, D. (1998) ‘On the synthesis of 2-Amino-4,6-difluorobenzonitrile: Highly Selective Formation of 5-Fluoro-3-nitro-1,2-benzoquinone 2-diazide in the Attempted Sandmeyer Cyanation of 2,4-Difluoro-6-nitrobenzenediazonium cationJournal of chemical research , pp. 144-145. ISSN 1747-5198

1996

Camps, P., Elachab, R., Font-bardia, M., Gorbig, D., Morral-Cardoner, J., Munoz-torrero, D., Solans, X. and Simon, M. (1996) ‘Easy synthesis of 7-alkylbicyclo[3.3.1]non-6-en-3-ones by silica gel-promoted fragmentation of 3-alkyl-2-oxaadamant-1-yl mesylatesTetrahedron , 52 (16), pp. 5867-5880. ISSN 0040-4020