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Selected Publications
Roberts, R.L., Wallace, M.C., Seinen, M.L., Van Bodeegraven, A.A., Krishnaprasad, K., Jones, G.T, Van Rij, A.M., Baird, A., Lawrence, I.C., Prosser, R., Bampton, P., Grafton, R., Simms, L.A., Studd, C., Bell, S.J., Kennedy, M.A., Halliwell, J., Gearry, R.B., Radford-Smith, G., Andrews, J.M., McHugh, P.C and Barclay, M.L. Non-Synonymous Polymorphism in Guanine Monophosphate Synthetase is a risk factor for Unfavourable Thiopurine Metabolite Ratios in Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases. Accepted March 2018.
DA Buckley, EM Jennings, NN Burke, M Roche, V McInerney, JD Wren, The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain. Molecular neurobiology 55 (3), 2420-2430 2018.
Ward, S., Page, M.I., McHugh, P.C and Powels, N.T. Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS. Analytical Methods; 9 (41): 5929-34. 2017.
P Zis, A Paladini, A Piroli, PC McHugh, G Varrassi, M Hadjivassiliou, Pain as a first manifestation of paraneoplastic neuropathies: a systematic review and meta-analysis. Pain and therapy 6 (2), 143-151 2017.
Zis, P. Strydom, A, Buckley, D, Adekitan, D, McHugh, P.C. Cognitive ability in Down Syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity. Neuroscience Letters. 254-257, 2017.
Adams, K., Ball, A.K., Birkett, J., Brown, L., Chappell, B., Gill, D.M., Lo, P. K. T., Patmore, N.J., Rice, C.R., Ryan, J., Raubo, P., Sweeney, J.B., (2016) An iron-catalysed C–C bond-forming spirocyclization cascade providing sustainable access to new 3D heterocyclic frameworks. Nature Chemistry ISSN: 1755-4330
Dunnill, C. J., Ibraheem, K., Mohamed, A., Southgate, J. and Georgopoulos, Nikolaos T. (2016) A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis. Oncogene. ISSN 0950-9232
Onasanwo, Samuel, Velagapudi, Ravikanth, El-Bakoush, Abdelmeneim and Olajide, Olumayokun A (2016) Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism. Molecular and Cellular Biochemistry, 414 (1). pp. 23-36. ISSN 0300-8177
Emamzadeh, F., Aojula, H., McHugh, P. and Allsopp, D. (2016) ‘Effects of different isoforms of apoE on aggregation of the alpha-synuclein protein implicated in Parkinson’s disease ’ Neuroscience Letters , 618, pp. 146-151. ISSN 0304-3940
Phillips, R (2016) ‘Targeting the hypoxic fraction of tumours using hypoxia activated prodrugs ’ Cancer Chemotherapy and Pharmacology , 77 (3), pp. 441-457. ISSN 0344-5704
Maskell, P., Smith, P., Cole, R., Hikin, L. and Morley, S. (2016) ‘Seven fatalities associated with ethylphenidate ’ Forensic Science International , 265, pp. 70-74. ISSN 03790738
Newman, J., Cooper, C., Roos, A., Aitkenhead, H., Oppermann, U., Cho, H., Osman, R. and Gileadi, O. (2016) ‘Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding ’ PLoS ONE , 11 (2), pp. 1-20. ISSN 1932-6203
Okorji, U., Velagapudi, R., El-Bakoush, A., Fiebich, B. and Olajide, O. (2015) ‘Antimalarial drug artemether inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms ’ Molecular Neurobiology . ISSN 1559-1182
Zis, P., McHugh, P., McQuillin, A., Praticò, D., Dickinson, M., Shende, S., Walker, Z. and Strydom, A. (2014) ‘Memory Decline in Down Syndrome and Its Relationship to iPF2alpha, a Urinary Marker of Oxidative Stress ’ PLoS ONE , 9 (6), p. e97709. ISSN 1932-6203
Airley, R., McHugh, P., Evans, A., Harris, B., Winchester, L., Buffa, F., Al-Tameemi, W., Leek, R. and Harris, A. (2014) ‘Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression ’ British Journal of Cancer , 110, pp. 715-723. ISSN 0007-0920
Faulkner, A., Kaner, R., Abdallah, Q., Clarkson, G., Fox, D., Gurnani, P., Howson, S., Phillips, R., Roper, D., Simpson, D. and Scott, P. (2014) ‘Asymmetric triplex metallohelices with high and selective activity against cancer cells ’ Nature Chemistry , 6 (9), pp. 797-803. ISSN 17554330
Joyce, P., Stephenson, J., Kennedy, M., Mulder, R. and McHugh, P. (2014) ‘The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder ’ Frontiers in Genetics: Behavioural and Psychiatric Genetics , 4 (313). ISSN 1664-8021
Georgopoulos, N., Kirkwood, L. and Southgate, J. (2014) ‘A novel bidirectional positive feedback loop between Wnt/ -catenin and EGFR/ERK: role of context-specific signalling crosstalk in modulating epithelial tissue regeneration ’ Journal of Cell Science , 127 (13), pp. 2967-2982. ISSN 0021-9533
Paus, R., Haslam, I., Sharov, A. and Botchkarev, V. (2013) ‘ Pathobiology of chemotherapy-induced hair loss ’ The Lancet Oncology , 14 (2), p. e50-e59. ISSN 1474-5488
Wright, J., McHugh, P., Pan, S., Cunningham, A. and Brown, D. (2013) ‘Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level ’ Molecular and Cellular Neuroscience , 57, pp. 33-41. ISSN 1044-7431
