Impact
Suspended Additive Layer Manufacturing: A solution to 3D printing with low viscosity bioinks
Our research on Suspended Additive Layer Manufacturing (SALM) opened up a radically new approach to 3D Bioprinting with low viscosity bioinks, with applications in tissue engineering and regenerative medicine. We identify:
Healthcare impacts in allowing a greater range of hydrogel materials to be used in 3D bioprinting for soft tissues and to create tissue models for studying disease states and potential therapeutics
Category of impact: Technological impact.
Related Outputs
Moxon, S., Cooke, M., Cox, S., Smow, M., Jeys, L., Jones, S., Smith, A.* and Grover, L.* (2017) ‘Suspended manufacture of biological structures’ Advanced Materials. 29 1605594
Cooke, M.E., Snow, M., Nandra, R., Holton, J., Chouhan, G., ter Horst, B., Esmaeli, M., Hill, L., Moakes, R., Jones, S.W., Williams, R., Moiemen, N., Smith, A.M., & Grover L.M (2018) Structuring of soft materials across multiple length scales for biomedical applications, Advanced Materials 1705013
Senior, J., Cooke, M., Grover, L.* and Smith, A.* (2019) ‘Fabrication of complex hydrogel structures using suspended layer additive manufacturing (SLAM)’ Advanced Functional Materials. In Press
Bioactive Peptides
Natural peptides derived from meat waste are bioactive compounds with nutritional, functional and biological activities. In collaboration with Biofac A/S, Denmark our research has identified Peptide fractions displaying high bioactivity for further refinement of existing BIOFAC products and creating a new platform for the production and development of new peptide products.
Category of impact: Health impact, Economic Impact
Publications:
BIOFAC website article
Pearman, N.A., Ronander, E., Smith, A.M., Morris, (2020) The identification and characterisation of novel bioactive peptides derived from porcine liver, Current Research in Food Science, 3, 314-321
Heparin Analysis
Heparin is bioactive compounds derived mainly from pig mucosa and is used therapeutically for its anticoagulant activity. In collaboration with Leo Pharma, Copenhagen/Cork our research has identified progressive effects of environmental conditions on heparin structure and identified mechanisms of degradation in industrial process environments and proposed ways to improve the manufacturing processes and optimize the storage conditions of products containing pharmaceutically active heparin.
Furthermore, the research proposes alternative routes to certain modifications of heparin that may contribute to the preparation of new bioactive heparin-based derivatives.
Category of impact: Health impact, Economic Impact
Publications
Kozlowski, A.M., Yates, E.A., Roubroeks, J.P., Tømmeraas, K., Smith, A.M., Morris, G.A. (2021) Hydrolytic Degradation of Heparin in Acidic Environments: Nuclear Magnetic Resonance Reveals Details of Selective Desulfation, ACS Applied Materials and Interfaces, 13(4), pp. 5551–5563
UK Hydrocolloids Symposium Series
Founded and Chaired by Smith, Kontogiorgos, and Morris in 2013 and was held at the University of Huddersfield. This is now a biennial symposium for students, academics and industrialists to present their research and to promote sharing of ideas between disciplines for hydrocolloid applications. The 2nd Hydrocolloids Symposium was hosted by the University of Birmingham 10th September 2015 and the 3rd Hydrocolloids Symposium by University of Nottingham 13th September 2017. The 4th UK Hydrocolloids Symposium was held at the University of Leeds 12th September 2019.
