Transdermal drug delivery

Transdermal delivery offers several advantages over traditional drug delivery routes such as oral and parenteral including elimination of first pass metabolism, minimization of pain, and the potential to sustain release of drugs over extended periods. However, transdermal transport of drugs is slow due to low permeability of stratum corneum, the uppermost layer which provides the major barrier to uptake. Various enhancers, both physical and chemical, including chemicals, electric fields, and ultrasound have been used to enhance transdermal drug penetration.

Micro and nanoemulsions are attractive drug delivery vehicles for transdermal delivery and we have been working on a combination of strategies to enhance transdermal delivery.

Microemulsions as topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester (TMZA-HE). P. Suppasansatorn, U. Nimmannit, B.R. Conway, L. Du, Y.F. Wang. Journal of Pharmacy and Pharmacology, 2007, 59 (6) 787-794

Skin delivery, potency and antitumor activities of temozolomide ester prodrugs.  P. Suppasansatorn, G. Wang, B.R. Conway, W. Wang, and Y.F. Wang. Cancer Letters, 2006, 244 (1), 42-52

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